BLOOD SCIENCES ARTICLES

With the association between plasma viscosity and cardiovascular disease having been documented extensively and for some time, David Norcliffe and David Manuel revisit some of these studies to explore how haemorheology and measuring clinical viscosity could play a significant role in the monitoring and early detection of CVD.

It has been long established that circulatory and vascular changes play a significant role in long-term complications of diabetes. David Norcliffe and David Manuel explore how clinical viscosity testing could play a role in the care pathways of diabetes patients.

In the UK and Europe, too many cases of gastric cancer are still coming to light at a later, less treatable stage. In contrast, high-risk Asian countries have shown real progress in significantly improving outcomes by screening populations for early signs of the disease. Tamara Matysiak-Budnik discusses how we can learn from the progress that has been made in high-incidence countries, and explores a multi-step testing approach.

In diagnostic testing errors can occur at any stage of testing, with pre-analytical interference from haemolysis, icterus, and lipaemia (HIL) being particularly common. HIL interference can lead to inaccurate results and is therefore a major concern for clinical laboratories. Jason Armstrong explores the causes and effects of HIL interference and discuss strategies for its detection and mitigation in clinical laboratory analysis.

In the second of two articles for Pathology in Practice, retired biomedical scientist David Norcliffe, with David Manuel, looks at how clinical viscosity testing can be used more widely, with the measurement of viscosity having a considerable number of possible applications which are receiving further investigation.

Graham Johnson discusses how gastroenterology has changed over the past 20 years. He looks at how non-invasive diagnostic testing, prior to endoscopy, could provide a solution to earlier detection and better outcomes for upper gastrointestinal disorders.

In part one of a two-part series David Norcliffe presents a study of clinical viscosity, outlining how it is measured and how it is used as part of the diagnosis of various conditions. Part two – to run in the next issue – looks at future applications of this technology.

Pre-eclampsia remains a common complication during pregnancy, but the methods used to initially determine the presence of the disease still rely on simple non-specific parameters. Testing for placental growth factor has huge potential to improve management of a condition that is challenging to diagnose explains Dawn Hannah, clinical educator at Quidel.

Two companies have recently joined forces with the aim of reducing errors in the preanalytical phase following blood collection and before samples arrive in the laboratory.

Endoscopy is considered the ‘gold standard’ method for investigating dyspeptic symptoms caused by Helicobacter pylori. Professor Peter Malfertheiner discusses the advantages offered by non-invasive ‘serological biopsy’ in the gastric cancer care pathway and management of atrophic gastritis.

The early stages of chronic kidney disease are usually asymptomatic, with diagnosis only achieved following blood or urine tests undertaken for another reason. Now, National Institute for Health and Care Excellence guidance is highlighting the value of these simple tests, which have been the focus of a recently published study.

Introducing a new, high-sensitivity test to detect blood-based biomarkers of mild traumatic brain injury within 12 hours of head trauma, which gives clinicians the power to predict the absence of intracranial lesions in adult patients with suspected mild traumatic brain injury.

North West London Pathology has developed a hub-and-spoke network with clinical need at its forefront across seven hospital sites, supported by Stago UK’s resources and its reputation for adaptability.

Methotrexate is used to treat patients with severe psoriasis, but is associated with hepatoxicity. Here, Nicola McDonagh undertakes verification and evaluation of the Siemens ELF Profile test as a marker of the degree of liver fibrosis in such cases.

Accurate diagnosis of GI disease is fundamental for appropriate patient management. Focusing on four common diseases, Carolyne Horner describes how a selection of commercial kits may supplement diagnostic methods and support diagnosis.