Lentigo maligna: value of PRAME/Melan A IHC double-labelling

Immunohistochemistry is a vital tool in the classification of skin lesions. Here, Rasiyan Salih and colleagues explore and assess the value of double labelling for PRAME and Melan A expression as an improved marker for slow Mohs margin assessment of lentigo maligna.

New solution offers high quality, high speed staining and adaptable workflows

The recent BOND-PRIME launch by Leica Biosystems introduces technological advancements to help laboratories maintain staining quality with increased workloads. Novel staining technology ensures even tissue coverage, with active fluid control and airgapped exchange to minimise the risk of carryover; while the system incorporates all aspects of Universal Access offering ultimate flexibility.

Combining AI and whole slide imaging: a faster way to evaluate lupus nephritis

Evaluating lupus nephritis presents significant challenges, with pathological evaluation requiring the participation of experienced pathologists, as well as being timeconsuming and prone to human error and misjudgement. Here, Wei Juan Wong explains how a combination of whole-slide imaging and artificial intelligence accelerates this important work.

Problems to be solved; work to be done – reducing errors and lost samples

The Anatomical Pathology laboratory at the Cardiff and Vale University Health Board services the needs of a sizable local population, as well as specialist services further into Wales and other surrounding areas. Here Pathology in Practice learns how a commercial partnership has enabled significant improvements in reducing errors and lost samples by implementing new systems for sample tracking and storage.

Automated tissue dissection: its role in personalised medicine

Automating tissue dissection would appear to hold the key to personalised medicine becoming a reality. Here, Pathology in Practice has been given an early look at a new Xyall solution for the molecular pathology laboratory.

Xylene-free tissue processing: good results, less solvent exposure

The use of xylene-free processing in histopathology has gained ground in recent years, supported by the latest developments in tissue processor technology. Here, Epredia customers in Germany provide examples of the advantages to processes and personnel gained through a simple change in methodology.

Large-scale soft tissue sarcoma study: introducing a veterinary partnership

The Veterinary Pathology Group – a member of SYNLAB UK and Ireland – has announced that it is partnering with Fitzpatrick Referrals to conduct a canine soft tissue sarcoma study to improve clinical practice and subsequent patient outcomes.

Advances in surgical specimen management across North Wales

In order to optimise and standardise handling of surgical specimens, Betsi Cadwaladr University Health Board adopted an innovative vacuum-packing solution across its three main hospital sites in North Wales, reducing formalin use, improving quality and cutting costs.

Expression of PRAME in melanocytic lesions: significance and evaluation

Immunohistochemistry is a vital tool in the classification of melanocytic skin lesions. Here, Karolina Wojcik and colleagues assess PRAME expression as a new marker in recognising and distinguishing the malignant melanomas from atypical naevi.

Microscopy of cutaneous malignancies: an H&E subtype evaluation

Frozen section and H&E staining are an integral part of the support for patients undergoing Mohs micrographic surgery. Here, Jeyrroy Gabriel and colleagues report on a focused assessment of haematoxylin staining sensitivity and specificity.

Twenty first-century Lean tissue processing: LOGOS customer experiences

A new era of optimal tissue processing has been introduced, offering xylene-free ultra-rapid protocols. Here, Menarini Diagnostics provides an overview and reports on a trio of customer experiences using the system.

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