HISTOPATHOLOGY ARTICLES

Immunohistochemistry is a vital tool in the classification of skin lesions. Here, Rasiyan Salih and colleagues explore and assess the value of double labelling for PRAME and Melan A expression as an improved marker for slow Mohs margin assessment of lentigo maligna.

The recent BOND-PRIME launch by Leica Biosystems introduces technological advancements to help laboratories maintain staining quality with increased workloads. Novel staining technology ensures even tissue coverage, with active fluid control and airgapped exchange to minimise the risk of carryover; while the system incorporates all aspects of Universal Access offering ultimate flexibility.

Evaluating lupus nephritis presents significant challenges, with pathological evaluation requiring the participation of experienced pathologists, as well as being timeconsuming and prone to human error and misjudgement. Here, Wei Juan Wong explains how a combination of whole-slide imaging and artificial intelligence accelerates this important work.

The Anatomical Pathology laboratory at the Cardiff and Vale University Health Board services the needs of a sizable local population, as well as specialist services further into Wales and other surrounding areas. Here Pathology in Practice learns how a commercial partnership has enabled significant improvements in reducing errors and lost samples by implementing new systems for sample tracking and storage.

Automating tissue dissection would appear to hold the key to personalised medicine becoming a reality. Here, Pathology in Practice has been given an early look at a new Xyall solution for the molecular pathology laboratory.

The use of xylene-free processing in histopathology has gained ground in recent years, supported by the latest developments in tissue processor technology. Here, Epredia customers in Germany provide examples of the advantages to processes and personnel gained through a simple change in methodology.

The Veterinary Pathology Group – a member of SYNLAB UK and Ireland – has announced that it is partnering with Fitzpatrick Referrals to conduct a canine soft tissue sarcoma study to improve clinical practice and subsequent patient outcomes.

In order to optimise and standardise handling of surgical specimens, Betsi Cadwaladr University Health Board adopted an innovative vacuum-packing solution across its three main hospital sites in North Wales, reducing formalin use, improving quality and cutting costs.

Immunohistochemistry is a vital tool in the classification of melanocytic skin lesions. Here, Karolina Wojcik and colleagues assess PRAME expression as a new marker in recognising and distinguishing the malignant melanomas from atypical naevi.

Frozen section and H&E staining are an integral part of the support for patients undergoing Mohs micrographic surgery. Here, Jeyrroy Gabriel and colleagues report on a focused assessment of haematoxylin staining sensitivity and specificity.

A new era of optimal tissue processing has been introduced, offering xylene-free ultra-rapid protocols. Here, Menarini Diagnostics provides an overview and reports on a trio of customer experiences using the system.