Bacterial detection for healthcare: is BSRMA the start of a new era?

Following development in the military setting, the bacteria-specific rapid metabolic assay could take a step closer to a new era in bacterial detection. Here, Andrew Kemp provides an overview of progress.

Fresh tissue handling pathway for the 100,000 Genomes Project

In order to optimise and standardise the handling of fresh tissue for the 100,000 Genomes Project, four partner trusts of the West Midlands Genomic Medicine Centre have adopted an innovative vacuum-packing solution.

Prion diseases: a brief look in the current literature

Prion diseases or transmissible spongiform encephalopathies are a family of rare progressive neurodegenerative disorders that affect both humans and animals. A recent confirmed case of bovine spongiform encephalopathy in Scotland has brought this devastating group of diseases, that are usually rapidly progressive and always fatal, back into focus.

Serious Hazards of Transfusion scheme: a review of 2017 data

Laboratory incidents specialist Hema Mistry summarises the 2017 SHOT Annual Report, and looks at why the same errors continue to occur and how many of them could have been prevented.

Calprotectin and elastase: update on faecal testing for gastrointestinal diseases

Screening of faecal samples for blood and microorganisms is commonplace, yet testing that can distinguish irritable from inflammatory bowel conditions, and detect pancreatic exocrine insufficiency. is equally important, as this review illustrates.

Clinical and Laboratory Haemostasis 2018: a UK NEQAS BC update

Tim Woods collates abstracts that reflect proceedings of the UK NEQAS for Blood Coagulation annual scientific and participants’ two-day meeting, which was held in Sheffield earlier in the year.

Tuberculosis: a view of bioinformatics, molecular typing and spoligotyping

Over the past decade, much research effort has been invested in the genomics and epidemiology of Mycobacterium tuberculosis infection, one of the world’s deadliest diseases. Currently, scientific and political initiatives aim to improve the situation.

Statistical quality control: overview of applications in the clinical laboratory

Following the recent publication of his successful articles on measurement uncertainty, Stephen MacDonald returns with the first in a new series looking at internal quality control in laboratory medicine.

Lymphoid leukaemia: a look at the genetics of proliferation

Treatment of acute lymphoblastic leukaemia in children is one of the great success stories of cancer medicine. Genetic analysis continues to have a major role in the fight against this and other lymphoid leukaemias.

Nostalgia or a reality check for the IVD industry: a brief history of change

As we move through yet more amalgamation, consolidation, change – call it what you will – a time for reflection and prediction is always worthwhile. Here, Mark Reed offers a brief history of change.

Are you ready for primary molecular screening for human papillomavirus?

The NHS Cervical Screening Programme is set to replace cytology screening with the molecular HPV test as the primary form of screening. Here we discuss the impact of this change and the role of a trusted partner in this process.

Next-generation IFA testing: teaching an old dog new tricks

Jake Morrow looks at the current state of autoantibody testing, what impact this has on provision of the service, and what the future holds for this important area of autoimmunity and immunology.

Measles prevention and virus function: a brief look in the current literature

Figures released by Public Health England indicate that the numbers of laboratory-confirmed cases of measles increased hugely between 2017 (n=274) and the first half of 2018 (n=738). Recently published articles on the subject from around the world suggest that issues related to poor vaccination uptake and also increased immigration and the associated importation of the virus are just two of a number of reasons for this increase in infection.

Rapid diagnostics – time is relative: a BSMT Annual Scientific Meeting report

Mark Wilks reports on the Annual Scientific Conference of the British Society for Microbial Technology, held at Public Health England, Colindale, London, earlier this year.

Point-of-care testing in microbiology: an overview

The application of point-of-care testing has become commonplace across much of diagnostics. Here, Sarah Pitt looks at the situation in microbiology and how this technology can benefit patient care and infection control.

Translational research: designing the route from bench to bedside

David Martin discusses the role of architectural best practice in supporting translational research, to ensure innovations in the laboratory are transposed rapidly into successful improvements in patient outcomes.

Microbe 2018: a brief preview of scientific and commercial excellence

This year’s Microbe symposium, the 17th biennial event in this series, will return to Sheffield in September. Here, Pathology in Practice provides a preview, including the vital commercial element of proceedings.

Cardiac troponins and the diagnosis of heart disease: some articles in the current literature

Cardiac troponin T (cTnT) and troponin I (cTnI) are cardiac regulatory proteins that control the calcium-mediated interaction between actin and myosin. Raised cardiac troponin concentrations are now accepted as the standard biochemical marker for the diagnosis of myocardial infarction.

Optimising Mohs clinic flow and patient treatment: the vital role of cryotomy

The University Hospital of Wales, Cardiff, has pioneered Mohs micrographic surgery since 1992, providing optimal patient care and rapid skin cancer treatment. Central to fast treatment time is cryosectioning, which is facilitated by use of the Thermo Scientific Cryostar NX70.

UK NEQAS: coordinating point-of-care testing

Point-of-care testing is vitally important in many areas of 21st-century healthcare, and requires medical laboratory overview to ensure a safe an efficient service. External quality assessment is an important aspect of this assurance, as this report illustrates.