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Post-transcriptional gene regulation and the role of microRNAs

For their discovery of microRNAs, the Americans Victor Ambros and Gary Ruvkun received this year’s Nobel Prize in Physiology or Medicine. Here, Pathology in Practice Science Editor Brian Nation compiles a selection of current research interest in these tiny RNA molecules that play a crucial role in health and disease.

MicroRNA-206 in human cancer: Mechanistic and clinical perspectives

Bahari Khasraghi L, Nouri M, Vazirzadeh M et al. Cell Signal. 2023 Jan; 101: 110525. doi:10.1016/j.cellsig.2022.110525.

MicroRNAs (miRNAs), small non-coding RNAs approximately 20-25 nt in length, play important roles via directly binding to the corresponding 3’ UTR of target mRNAs. Recent research has shown that miRNAs cover a wide range of diseases, including several types of cancer. 

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