Reducing parasitic disease in Africa: multinational research

Cutting-edge flow cytometry is underpinning a pioneering multinational research initiative designed to transform the lives of those suffering from leishmaniasis, a disfiguring and potentially life-threatening parasitic disease.

Interleukin-7 and its effects: a brief look in the literature

Recent press coverage of COVID-19 disease has highlighted a possible role for interleukin-7 in boosting T-cell numbers and aiding recovery. However, the current literature reports on a wide range of other benefits of this important cytokine.

Pandemic coronavirus: an overview of SARS-CoV-2 and COVID-19 disease

Pathology faces a major challenge to detect the new coronavirus, and to provide laboratory support to COVID-19 patients. Sarah Pitt provides an overview of the virology, epidemiology and laboratory diagnosis of this latest agent of disease.

Antimicrobial efficacy and lack of resistance to silane quaternary com

Does the ‘entourage effect’ explain the increase in antimicrobial efficacy and lack of resistance seen with fifth-generation silane quaternary compounds? Here, Andrew Kemp provides an overview of the development and use of such agents.

Automated algorithms for FVIII and FIX: inhibitor detection in haemophilia

The detection and monitoring of haemophilia remains a challenging process for laboratories; however, the introduction of testing algorithms is set to improve the quality and consistency of results while freeing staff time.

Coagulation profiler: proof-of-concept testing and development

Benson Viscometers is developing a novel device that can determine the clotting profile of a blood sample. Furthermore, the company also aims to develop the point-of-care capabilities of this device.

Artificial intelligence and digital pathology: a look to the future

As the pathologist workforce shrinks and workload increases, laboratory medicine is beginning to adopt advanced technology and robust AI solutions. Nathan Buchbinder and Scott Rayburn explain how digital solutions can change practice in pathology and the life sciences.

Group B Streptococcus: what are we missing in the newborn period?

Group B Streptococcus is the most common cause of severe infection in newborn babies in the UK. Despite a risk-based prevention strategy for early-onset infection, in place since 2002, rates have increased significantly.

Disinfectants and hand sanitisers: a new test of efficacy against viruses

Do hand sanitisers really work against viruses? Andrew Kemp and colleagues introduce a new methodology for testing the efficacy of disinfectants and sanitisers on surfaces and on the skin against viral isolates.

Total bile acids testing: fifth-generation method in cholestasis of pregnancy

The advanced enzyme cycling method for bile acids offers increased sensitivity and precision when compared to traditional enzymatic tests, as illustrated by its use in obstetric cholestasis diagnosis and monitoring.

Veterinary pathology in Kenya: charismatic and not so charismatic creatures

In terms of scope and geography, veterinary pathology in the field is an activity of wide horizons. In this review of a visit to Kenya, Margaret and John Cooper describe how they are committed to training the next generation of veterinary workers in East Africa.

Surgical site infections: a need to galvanise efforts to reduce occurrence

Surgical site infection continues to be a major source of concern to patients and the multidisciplinary teams involved in surgery. Sadly, however, evidence-based practice to reduce such infections is often slow to be implemented, as Kate Woodhead explains.

Cell-free DNA and testing for cancer: a brief look in the literature

Recent national news focused on the role that cell-free DNA (cfDNA) testing may have in detecting many different types of cancer. Here, a small selection from the current literature highlights future possibilities and some potential problems.

Coronaviruses in the literature: another beast from the Orient

Over the past decade, infections caused by coronaviruses have resulted in severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome. Now, a new coronavirus is causing worldwide concern, and is exercising the research community, as this small selection of very recently published articles illustrates.

A glass act: adhesion and clarity in the modern histopathology laboratory

Although often taken for granted, modern glass microscope slides, their characteristics and features can have an impact on test performance, diagnosis and laboratory workflow. Here, Mark Wilson looks at some of the features offered by Epredia products.

Clinical flow cytometry: advances in techniques and instrumentation

Clinical flow cytometry continues to feature in an eclectic range of applications in routine laboratory medicine and in the research environment. In addition to its use in haematology and immunology, flow cytometry has a cutting-edge role in investigating diverse biological processes, and the latest system developments offer innovation and increasing ease of use.

Point-of-care paediatric urine microscopy: a quality training model

Point-of-care testing is finding ever greater application outside the conventional medical laboratory. Here, audit of the use of phase contrast urine microscopy in paediatrics is explored in terms of training and quality, as Michelle Payne and Vikki Booth explain.

Blood culture audit: does transport time have an impact on positivity?

Alexander Mobbs and colleagues examine the effect that pre-analytical delay may have on the subsequent processing of blood cultures, and compare results obtained from two hospitals – one with an on-site laboratory, the other remote from the pathology service.

Use of beads to meet auditing requirements in histopathology

There is a surprising, yet cost-effective tool on the market that offers a solution to the issue of labelling tissue samples during the embedding process. And it is one that might remind you of days gone by, as Nicola Forsdyke explains.

Hospital-acquired pneumonia: impact of the Curetis Unyvero system

The increasing prevalence of antimicrobial resistance and the burden of disease due to hospital-associated pneumonia prompted Emma Jones and colleagues to investigate a molecular alternative to microbiological culture.