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Long COVID: could plasma viscosity detect inflammatory proteins?

David Manuel, David Norcliffe and Bernie Benson look at the prevalence of, and literature around, long COVID since the pandemic and consider measuring plasma viscosity as a diagnostic tool.

COVID-19, officially termed Coronavirus disease 2019, can be a severe viral illness.1 The virus responsible for this disease is Severe Acute Respiratory Syndrome Coronavirus 2, commonly abbreviated as SARS-CoV-2. Structurally the coronavirus has spikes containing proteins. The transmission of this virus commenced worldwide in late 2019 and rapidly developed into a global pandemic by the year 2020.

The disease COVID-19 is highly infectious and can cause a diverse variety of problems. It is spread primarily through infected droplets or saliva and aerosol discharge during coughing and sneezing.2 COVID-19 has been the causative agent implicated in over several million deaths worldwide during the pandemic.

Patients with coronavirus disease predominantly present with a respiratory tract infection. A proportion of these patients progress to a more severe and systemic disease, characterised by treatment-resistant pyrexia, acute lung injury with acute respiratory distress syndrome (ARDS), haematological manifestation, sepsis, followed by multiple organ failure with increased mortality.

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