Monitoring COVID-19 disease: the contribution of biological markers

Mandy Campbell from HORIBA Medical provides an overview of COVID-19 screening, prognosis and severity assessment, with a particular focus on the role of biomarkers and the value of point-of-care testing in the initial triage of patients.

Formalin fixation delivers quality biomarker results by NGS and IHC

A recent white paper published by Epredia examined the effective use of formalin fixation in the molecular study of tumour biomarkers, and included the results of a case study of three non-small-cell lung carcinomas of adenocarcinoma subtype.

Beating breast cancer: the latest biomarkers and breakthroughs

The mortality rate for breast cancer has fallen dramatically. The latest research offers hope for further improvements, not least through the introduction of highly sensitive blood tests and the innovative use of new and existing treatments.

Infection prevention is vital in the fight against AMR

At Infection Prevention and Control 2020, held in February, NHS leaders warned that increased efforts are required to reduce healthcare-associated infections, if we are to conquer the threat posed by antimicrobial resistance. Louise Frampton reports.

Biomedical Science Congress: a new planning challenge for 2021

While still over 12 months away, the Biomedical Science Congress is currently exercising the minds and the ingenuity of the organisers of this biennial event, as IBMS Deputy Chief Executive Sarah May explains.

Method comparison studies in biomedical science: an introduction

Following series on measurement uncertainty and internal quality control, Stephen MacDonald now turns his attention to method comparison, and here provides an introduction to what will be covered in the series in subsequent issues of the magazine.

Introducing NGS to the clinical microbiology laboratory: an update

The Annual Scientific Conference of the BSMT, due to take place last May, was cancelled. In this article, written on behalf of the BSMT, Mark Wilks collaborates with Adela Medina to summarise the presentation she planned to give at the event.

How COVID-19 moved the needle on the visible value of diagnostics

From the laboratory to the layperson, from pathologists to the public, the response to in vitro diagnostic testing has been engaging across all sectors of society during the current pandemic. Chris Hudson provides a view on the reaction from Roche.

Improving efficiency with new cutting-edge analysers at SWLP

An award-winning NHS partnership – South West London Pathology – recently installed DxH 900 haematology workcells from Beckman Coulter to enable its laboratories to provide a single, integrated pathology service to more than 3.5 million people.

Next-generation sequencing: a brief look in the literature

Diverse use of next-generation sequencing in histopathology and microbiology feature in the current issue; however, this molecular methodology is becoming ubiquitous across a wide range of clinical and laboratory applications.

Back at the coalface: a clinical virologist and the COVID emergency

Response to the current coronavirus pandemic has seen many retired personnel return to the clinical laboratory bench to help facilitate realisation of testing targets. Such altruistic action does reintroduce the returnee to the reality of change.

Microbiology testing networks: are they of value and fit for purpose?

Valerie Bevan looks at how microbiology testing networks have changed over the past 80 years, and how reflecting on this, and lessons from the current pandemic, might inform our response to future epidemics/pandemics.

Developing diagnostics for SARS-CoV-2: the role of reagents

Safely easing restrictions will require the development of extensive diagnostic capabilities, including rapid tests for use at the point of care. Andy Lane explains the role that diagnostics play and the importance high-quality reagents.

Blood coagulation: what’s new from the UK NEQAS BC scheme?

As a result of current restrictions, this year’s UK NEQAS BC annual scientific and scheme participants’ meeting was cancelled. Here, Ian Jennings, Dianne Kitchen and Anna Lowe are able to use Pathology in Practice to report.

How can RFID technology and flexible electronics help pathology?

With the NHS currently under huge strain, additional time-consuming and burdensome processes add to an already heavy workload. Gillian Ewers examines the advantages that radio frequency identification offers in tracking samples and consumables.

Coronavirus testing: a commercial view and post-analytical response

Against the ever-changing landscape of SARS-CoV-2 testing and an emerging need for sample storage, Mark Reed and Charlotte Duncan from Pro-Lab discuss a solution currently being adopted across the UK.

Delivery of pathology services: connectivity and engineering support

The recent coronavirus pandemic has clearly demonstrated the importance of remote working. This is reflected in the value of Stago’s data-sharing and instrument monitoring systems, highlighted in positive results obtained from a customer survey.

Histologists and molecular biology: meet the next generation

One of the two recognised early pathology disciplines, histopathology now combines modern practical laboratory techniques with sophisticated molecular biology methods,both of which facilitate the application of personalised medicine.

Plasma viscosity in COVID-19 disease: a vital monitoring role.

Establishing the diagnostic and prognostic value of measuring plasma viscosity in patients suspected or confirmed as having COVID-19 is currently underway in several UK hospitals. This article provides an overview of progress in research and practice

Fusobacterium infection: is Lemiérre’s disease the tip of an iceberg?

Is Fusobacterium necrophorum an underrated anaerobic pathogen, and could Lemiérre’s disease be prevented by earlier treatment of sore throat? Here, Mike Wren looks at the available evidence and illustrates some of the issues in two short case studies