Researchers at ETH Zurich have developed a new device for taking blood samples. It works according to the leech principle and is less invasive than taking blood from the arm with a needle. It is also easy to handle and can be used by people without medical training.
Although the new device cannot collect as much blood as a needle, it can collect significantly more than a finger prick. This makes diagnostic measurements more reliable.
At ETH Zurich (a public research university) researchers came up with the idea for the new device while previously developing something else: a suction cup that transports medication into the blood via the mucous membrane lining the inside of the mouth. “For this earlier project, we had already studied leeches, which attach to their host with a sucker. We realised that we could develop a similar system to collect blood,” says David Klein, a doctoral student in the group led by Jean-Christophe Leroux, Professor of Drug Formulation and Delivery at ETH Zurich.
After leeches have attached themselves, they penetrate the host’s skin with their teeth. To suck blood from the wound, they create negative pressure by swallowing. The new device works in a very similar way. A suction cup measuring about two and a half centimetres is attached to the patient’s upper arm or back. Within the cup are a dozen microneedles that puncture the skin when pressed against it. Within a few minutes, the negative pressure in the suction cup has ensured that sufficient blood has been collected to be used for diagnostic tests.
The new device is very cost-effective to produce, says Nicole Zoratto, a postdoc in Leroux’s group. She led the work on this development and is lead author of the study published in the journal Advanced Science. Zoratto also sees a future application for the new device in low-income regions such as sub-Saharan Africa, where it could play a major part in the fight against tropical diseases such as malaria. Diagnosing malaria involves taking blood from the patients.
Another advantage of the new device is that the microneedles are located within the suction cup. This minimises the risk of injury during the application and after disposal compared to blood sampling with conventional needles.
In the current version of the leech-like device, the suction cup is made of silicone and the microneedles concealed within are made of steel. However, the researchers are in the process of developing a new version made using fully biodegradable materials to create a sustainable product.
- Zoratto N, Klein-Cerrejon D, Gao D et al. A Bioinspired and Cost-Effective Device for Minimally Invasive Blood Sampling. Adv Sci (Weinh). 2024 Mar 7: e2308809. doi: 10.1002/advs.202308809. Online ahead of print.