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CytoFLEX nano flow cytometer pushes boundaries of EV detection

Beckman Coulter Life Sciences has launched its new CytoFLEX nano Flow Cytometer – the first purpose-built nanoscale flow cytometer for research use only that enables detection to at least 40 nm, enabling 30-50% more data creation.

With unrivalled sensitivity to detect, count, and characterise nanoparticles using a single analytical instrument, the CytoFLEX nano offers simultaneous multiparameter detection powered by six fluorescent detection channels and five side-scatter channels. It provides global laboratories with a first-of-its kind solution that lowers the limit of detection and increases resolution to characterise lower-abundance targets in heterogeneous extracellular vesicle (EV) populations between 1 μm and 40 nm (polystyrene when triggering on violet side scatter).

“The CytoFLEX nano shatters the previous limits of detection capabilities, arming researchers with data they previously would have never been able to access,” said Product Manager Matthew Goff. “This can open new doors for researchers and enable breakthrough discoveries in our battle against a myriad of diseases. Extracellular vesicles can be found everywhere, and now researchers finally have a tool to see what has always been right in front of them. We listened to the needs of our customers to create an analytical crossroads by increasing sensitivity through enhanced fluidics, optics, and electronics.”

Nanoparticles are introduced in a hydrodynamic focused stream to the optical system composed of lasers and detectors. Emitted signals are collected, digitised, and displayed by the electronics and instrument control software, CytExpert. Multiple automatic on-board cleaning options are offered to control sample-to-sample carryover and maintain a clean sample line.

“We need to go smaller to expand the realms of research, and there are very few instruments built for small particle detection alone,” said Alfonso Blanco, Director of the Flow Cytometry Core Technologies in the University College Dublin. “The CytoFLEX nano offers a goldmine of research discoveries, including the ability to develop complex biomarkers from blood or urine rather than more invasive tissue means, which means reduced pain for patients, along with richer results.”

The ergonomic design reduces noise, identifies backgrounds, and reduces carryover issues. Consistent instrument performance from extensive automated QC processes ensures consistent and reproducible results every time.

The CytoFLEX platform also includes the CytoFLEX, CytoFLEX S, and the CytoFLEX LX flow cytometers, along with the CytoFLEX SRT cell sorter for research, and the DxFLEX flow cytometer for diagnostic use. Learn more about the CytoFLEX nano instrument at https://www.beckman.com/flow-cytometry/research-flow-cytometers/cytoflex-nano.

 

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Upcoming Events

Pathology Horizons 2024

MacDonald Bath Spa Hotel, Bath
18-20 April, 2024

Diagnostics North East Conference 2024

The Catalyst, Newcastle upon Tyne
19 April, 2024

ECCMID 2024 - European Congress of Clinical Microbiology and Infectious Diseases

Fira Gran Via, 08038 Barcelona, Spain
27-30 April 2024

British Society for Microbial Technology Annual Microbiology Conference

UK Health Security Agency, Colindale, London
2 May 2024

EQA Reports: Interpreting Key Information & Troubleshooting Tips

ONLINE - Zoom
Thursday 16th May 2024

Participants’ Meeting: UK NEQAS Immunology, Immunochemistry & Allergy

Sheffield Hallam University, City Campus, Howard Street, Sheffield
24th May 2024

Access the latest issue of Pathology In Practice on your mobile device together with an archive of back issues.

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