EnteroBiotix, a full-spectrum microbiome therapeutics company, has announced a partnership with Imperial College London to develop microbiome R&D in patients suffering from blood cancer as well as accelerate systematic research in the new science of the microbiome.
EnteroBiotix and Imperial College are partnering to manage a Phase IIa investigator initiated trial, to evaluate how EBX-102 impacts on outcomes of bone marrow transplant patients with blood cancer. This trial forms part of the Microbiota Transplant Prior to Allogeneic Stem Cell Transplantation (MAST) study, run across six of the UK’s leading blood cancer centres and includes, along with Imperial, UCLH, The Royal Marsden, King’s College London, Leeds Teaching Hospitals, and University Hospitals Birmingham.
The company will provide its lead product, EBX-102, from its MHRA licensed facilities, for the clinical trial. EBX-102 contains diverse ecosystems of microbiota obtained from healthy and rigorously screened donors, offering a compositionally consistent drug product with attractive commercial attributes. EBX manufacturing capabilities include its novel proprietary AMPLA platform that enables rapid preparation of dry powder from hydrated starting material.
The Medical Research Council funded trial, supported in-kind by EnteroBiotix, will build on Imperial’s successful pilot study (in the same patient population) which demonstrated preliminary signals trending towards intestinal microbiota transplantation (IMT), reducing complications and improving survival. Imperial will increase exploration into the efficacy of this approach for a range of diseases, as well as to strengthen the route to commercialisation through systematic research.
Professor Julian Marchesi of Imperial College London, Department of Metabolism, Digestion and Reproduction, leading the research says: “Patients with blood cancers are a group whose gut microbiome is particularly under attack. They often receive strong chemotherapy, which has side effects of mouth ulcers and gut inflammation. Their nutrition might be poor, they receive frequent antibiotics because of their high rate of infections, and many of them end up colonised with antibiotic-resistant bacteria. That latter point in particular can be a problem when patients need a very demanding treatment, like bone marrow transplantation; haematologists are sometimes anxious about offering this or other treatments because patients are at such high risk of getting an infection which is untreatable. So, we are very excited and pleased to be partnering with EnteroBiotix to use their product to manipulate the gut microbiome in these patients.”
Dr James McIlroy, Founder and CEO of EnteroBiotix says: “When we founded EnteroBiotix there were 13 clinical trials listed on clinicaltrials.gov investigating IMT, now there are hundreds. Most of the studies published so far show the same thing – that transferring microorganisms from healthy to sick people can contribute to improving health outcomes.”
EnteroBiotix’s products have potential applicability across multiple disease areas including immuno-oncology and diseases of the liver-brain axis.
Pictured above are EnteroBiotix CEO Dr James McIlroy (centre) with Professor Julian Marchesi (left) and Dr Benjamin Mullish (right) of Imperial College London.
For more details see www.enterobiotix.com.