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PhoreMost enters multi-project drug target discovery collaboration with Roche

PhoreMost will deploy its Siteseeker platform to identify novel targets for Roche’s discovery programmes.

PhoreMost, the UK-based biopharmaceutical company dedicated to ‘Drugging the Undruggable’ disease targets, has entered into a multi-project target discovery collaboration with Roche, one of the world's leading biotechnology companies. Under the terms of the agreement, PhoreMost will receive an upfront payment and is eligible for preclinical success-based milestones. Further financial terms are not disclosed.

PhoreMost will deploy its in-house expertise and next-generation phenotypic screening platform, Siteseeker, toward disease-relevant pathways nominated by Roche. Novel targets identified will be further validated and characterised by Roche’s R&D organisation, and any Siteseeker-based probes would become the starting point for drug discovery efforts across a set of disease pathways in immunology and haematology.

The Siteseeker platform is based on PhoreMost’s core proprietary ‘Protein Interference’ (Proteini) technology. PhoreMost probes the entire proteome in a live cell environment for novel druggable targets linked to any chosen disease, using the vast 3-D shape diversity of natural protein fragment (sub-domain) libraries. Siteseeker systematically unmasks new and unanticipated druggable sites across the entire human proteome, directly linking them to useful therapeutic functions.

Dr Neil Torbett, CEO of PhoreMost, said: “This collaboration with Roche is testament to the power and versatility of Siteseeker, and further validates the potential and broad applications of the platform. We are delighted that Roche has chosen to work with us to enhance its drug discovery pipeline using Proteini and Siteseeker to identify novel targets and unlock the power of protein structure prediction for next generation drug design.”

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Upcoming Events

Arab Lab Live 2022

Dubai International Convention & Exhibition Centre Dubai World Trade Centre - Trade Centre - Trade Centre 2 - Dubai - United Arab Emirates
24 - 26 October 2022

Lab Innovations 2022

Hall 2 NEC, Birmingham
2 & 3 November 2022

MEDICA 2022

Messe Düsseldorf D-40474 Düsseldorf, Stockumer Kirchstraße 61
14 - 17 November 2022

Meeting demand: the changing picture of diagnostics

The King's Fund, London, W1G 0AN
16 November 2022

Access the latest issue of Pathology In Practice on your mobile device together with an archive of back issues.

Download the FREE Pathology In Practice app from your device's App store

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