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Uncertainty in antimicrobial susceptibility testing of Moraxella catarrhalis

Aini Suraya Nizam and Lynne Lawrance examine the role of uncertainty in antimicrobial susceptibility testing, following the introduction by EUCAST of the concept of the Area of Technical Uncertainty in this sector of medical microbiology.

Moraxella catarrhalis is a Gram-negative diplococcus and part of the normal flora of the upper respiratory tract with other bacteria such as the pneumococcus and Haemophilus influenzae. It commonly causes acute otitis media in children and serious lower respiratory tract infection in elderly and immunocompromised patients.1

The agar disk diffusion method for antibiotic susceptibility testing (AST) is currently used as the official method of AST in many clinical laboratories, due to its simple and well-standardised procedure.2 In 2019, the European Committee on Antimicrobial Susceptibility Testing (EUCAST) introduced a new concept called the Area of Technical Uncertainty (ATU) in AST.3

This study aimed to determine whether or not uncertainty of measurement affects the interpretation of an antimicrobial susceptibility testing measurement of M. catarrhalis. Its objectives are

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Upcoming Events

Haemovigilance Past, Present and Future

Regency Suite, Brighton Hilton Metropole
6–8 July

BSMT - The Genomic and Microbiology Revolution: In Technology We Trust?

Royal Air Force Museum, Hendon, London
19 July 2022

Arab Lab Live 2022

Dubai International Convention & Exhibition Centre Dubai World Trade Centre - Trade Centre - Trade Centre 2 - Dubai - United Arab Emirates
24 - 26 October 2022

Lab Innovations 2022

Hall 2 NEC, Birmingham
2 & 3 November 2022

MEDICA 2022

Messe Düsseldorf D-40474 Düsseldorf, Stockumer Kirchstraße 61
14 - 17 November 2022

Access the latest issue of Pathology In Practice on your mobile device together with an archive of back issues.

Download the FREE Pathology In Practice app from your device's App store

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