When running the one-stage activated partial thromboplastin time (APTT) method to manage haemophilia A patients, the CRYOcheck factor VIII-deficient plasma with Von Willebrand factor (VWF), from Precision Biologic, could improve assay performance.
It is currently the only commercially available manufactured FVIII-deficient plasma that compares to using congenital FVIII-deficient plasma. As access to congenital FVIII-deficient plasma is limited and has high donor variability and small pool sizes, this newly available product provides enhanced convenience and increased confidence in testing results.
The CRYOcheck FVIII-deficient plasma with VWF is manufactured from platelet-poor plasma. It has been immunodepleted of FVIII, and then purified VWF is reintroduced to normal levels. FVIII has been assayed at less than 1% normal antigen and activity levels, with VWF antigen and activity levels at >50%. The plasma is buffered and frozen, with the frozen format eliminating reconstitution errors and a 24-hour stability once thawed if refrigerated at 2–8°C in the original capped vial.
Precision Biologic provides a full range of factor-deficient plasmas, plus the Chromogenic Factor VIII and Factor VIII Inhibitor diagnostic kits.
www.alphalabs.co.uk/haemostasis
