Immunodiagnosis and immunotherapeutics based on human papillomavirus for HPV-induced cancers
Dong Z, Hu R, Du Y et al.
Front Immunol 2021 Jan 8; 11: 586796. doi: 10.3389/fimmu.2020.586796. eCollection 2020.
Infection with human papillomavirus (HPV) is one of the main causes of malignant neoplasms, especially cervical, anogenital and oropharyngeal cancers. Although we have developed preventive vaccines that can protect from HPV infection, there are still many new cases of HPV-related cancers worldwide. Early diagnosis and therapy are therefore important for the treatment of these diseases. As HPVs are the major contributors to these cancers, it is reasonable to develop reagents, kits or devices to detect and eliminate HPVs for early diagnosis and therapeutics. Immunological methods are precise strategies that are promising for the accurate detection and blockade of HPVs. During the last decades, t