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Innovation in sepsis management: rapid POC host response testing

Sepsis is a life-threatening reaction to an infection, resulting in the immune system overreacting and the beginning of damage to the body’s own tissues and organs. Here, Charlotte Duncan introduces the latest in point-of-care technology.

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.1 According to The UK Sepsis Trust, 250,000 people per year are affected by sepsis, of which 52,000 people die and 60,000 people suffer permanent, life-changing after effects.2 The often quoted aphorism that sepsis kills more people in the UK than bowel, breast and prostate cancer combined3 rather poignantly gives a sense of the scale of the problem.

                Indeed, the global picture is even more grim with sepsis causing an estimated 11 million deaths each year, and data showing those in vulnerable groups and low-resource settings account for 85% of these cases.4 In May 2017, the World Health Organization (WHO) issued a resolution confirming sepsis is a worldwide issue.5

                Given the significant disease burden in the UK, and globally, the diagnostic support to clinicians is lacking.6 Routine tests such as C-reactive protein (CRP), blood count, lactate7 and procalcitonin8 offer limited information on the inflammatory response of the patient in the form of ‘point-in-time’ assessments, requiring serial testing to obtain an indication of response to treatment, while most innovation focuses on bloodstream infections and subsequent identification and antimicrobial susceptibility testing (AST). Identification of a pathogen can allow clinicians to optimise antimicrobial therapy. Depending on the identification and AST result of an infecting organism, escalation or de-escalation of antibiotics and adjusting modes of administration can result in improved patient care9 and outcome, and support antimicrobial stewardship.10

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Upcoming Events

Microbiology Society Annual Conference 2023

Birmingham International Convention Centre.
17-20 April 2023

British Society for Microbial Technology Annual Microbiology Conference

Royal Air Force Museum, Hendon, London
11 May 2023

Microscience Microscopy Congress 2023 (mmc 2023, incorporating EMAG 2023)

Manchester Central Conference Centre
4-6 July 2023

IBMS Congress 2023

ICC Birmingham
25-28 September 2023

Access the latest issue of Pathology In Practice on your mobile device together with an archive of back issues.

Download the FREE Pathology In Practice app from your device's App store

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