Laboratory diagnosis of emerging human coronavirus infections – the state of the art
Loeffelholz MJ, Tang YW. Emerg Microbes Infect 2020; 9 (1): 747–56. doi: 10.1080/22221751.2020.1745095.
The three unprecedented outbreaks of emerging human coronavirus (HCoV) infections at the beginning of the twenty-first century have highlighted the necessity for readily available, accurate and fast diagnostic testing methods. The laboratory diagnostic methods for human coronavirus infections have evolved substantially, with the development of novel assays as well as the availability of updated tests for emerging ones. Newer laboratory methods are fast, highly sensitive and specific, and are gradually replacing the conventional gold standards.
This article reviews current laboratory methods available for testing coronaviruses by focusing on the coronavirus disease 2019 (COVID-19). Viral pneumonias typi