Biotage has launched the Biotage PhyPrep, a new automated platform for plasmid DNA purification that releases laboratory staff from the tedium of a repetitive, manual procedure.
The platform takes full advantage of the PhyTip columns’ dual flow chromatography technology, to yield supercoiled, endotoxin-free, transfection-grade plasmid DNA.
Plasmid DNA (plasmids) serve as important tools in life science and biotechnology industry and academic laboratories. Plasmids are commonly used to clone and amplify or express particular genes. A wide variety of plasmids are commercially available for such uses.
Plasmids are commonly being used in drug discovery and development for biopharmaceuticals. The most commonly used applications for plasmids are bacterial vector cloning, protein production, gene therapy and different disease models, which is in line with Biotage’s ‘HumanKind Unlimited’ focus.
With the new Biotage PhyPrep platform, the automated process of purifying plasmid DNA reduces the risk of human error, and with each sample being handled in the same way, the plasmid yield and purities are more consistent. Many laboratories currently outsource plasmid purifications – those laboratories can now bring that work in-house, improving process control, project deliverability while at the same time reducing costs.
Biotage PhyPrep is the first automated solution for plasmid purification in Maxi, Mega and Giga scales. The various scales differ in the volume of cell culture to be purified, with desired yields ranging from 1 mg to 10 mg of plasmid DNA.
“The launch of the Biotage PhyPrep will assist laboratories in discovering new therapies for patients, utilising biological drug molecules such as antibodies and novel gene therapies. A perfect match with the Biotage ethos of ‘HumanKind Unlimited’ – sustainably releasing the potential of science to address the issues faced by global society, making the world healthier, greener and cleaner,” states Tomas Blomquist, CEO Biotage.