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Hypercoagulability and cancer: a thrombin generation analyser role

Results of a recent clinical study using a fully automated, standardised thrombin generation analyser have shown that it is possible to identify breast cancer patients who are at high risk of disease recurrence.

A diagnosis of cancer increases the risk of venous thromboembolism (VTE) for all patients, accounting for up to 20% of cases,1 with thrombosis the second leading cause of death after the disease itself.2,3

            Breast cancer is the most common malignant disease worldwide, with women facing a three- to four-fold increased risk of VTE compared to those of the same age without the disease.4 Cancer-associated hypercoagulability is also linked to a greater chance of early disease recurrence (E-DR).5 Survival too is reduced,6 even when prognosis would otherwise be relatively good.

            One imperative for clinical research has been to find more accurate prognostic cancer biomarkers, especially for high-risk patients. A recent prospective study charts significant progress in E-DR by validating the role of thrombin generation (TG), and its measurement, when using the fully automated, standardised TG analyser, Stago’s ST Genesia.7,8

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Upcoming Events

Pathology Horizons 2024

MacDonald Bath Spa Hotel, Bath
18-20 April, 2024

Diagnostics North East Conference 2024

The Catalyst, Newcastle upon Tyne
19 April, 2024

ECCMID 2024 - European Congress of Clinical Microbiology and Infectious Diseases

Fira Gran Via, 08038 Barcelona, Spain
27-30 April 2024

British Society for Microbial Technology Annual Microbiology Conference

UK Health Security Agency, Colindale, London
2 May 2024

EQA Reports: Interpreting Key Information & Troubleshooting Tips

ONLINE - Zoom
Thursday 16th May 2024

Participants’ Meeting: UK NEQAS Immunology, Immunochemistry & Allergy

Sheffield Hallam University, City Campus, Howard Street, Sheffield
24th May 2024

Access the latest issue of Pathology In Practice on your mobile device together with an archive of back issues.

Download the FREE Pathology In Practice app from your device's App store

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