Hepatitis B, a potentially life-threatening liver infection caused by the hepatitis B virus (HBV), is a major global health problem. It can cause chronic infection and puts people at high risk of death from cirrhosis and liver cancer.
HBV genome and life cycle
Wang J, Huang H, Liu Y et al. Adv Exp Med Biol. 2020; 1179: 17–37. doi: 10.1007/978-981-13-9151-4_2.
Chronic hepatitis B virus (HBV) infection remains a serious threat to public health and is associated with many liver diseases including chronic hepatitis B (CHB), liver cirrhosis, and hepatocellular carcinoma. Although nucleos(t)ide analogues (NA) and pegylated interferon-α (Peg-IFNα) have been confirmed to be efficient in inhibiting HBV replication, it is difficult to eradicate HBV and achieve the clinical cure of CHB. Therefore, long-term therapy has been recommended for CHB treatment under the current antiviral therapy.
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