Anti-certolizumab pegol inhibitory antibodies
Bio-Rad Laboratories has launched a range of anti-certolizumab pegol inhibitory antibodies to support the development of assays for therapeutic drug monitoring of tumour necrosis factor-alpha (TNFα) inhibitors.
By extending its offering to include anti-certolizumab pegol antibodies, Bio-Rad offers critical reagents to support the development of anti-drug antibody (ADA) assays for all five marketed TNFα-inhibitor biologics and their biosimilars.
The range of recombinant monoclonal anti-idiotypic antibodies comprises three antibodies that are highly specific for the monoclonal antibody Fab fragment certolizumab pegol (Cimzia) and inhibit the binding of this drug to its TNFα target. The antibodies are fully human in full length IgG format and can be used as a surrogate positive control or calibration standard for an ADA assay to measure levels of patient anti-drug antibodies.
TNFα inhibitors are used to treat a wide range of inflammatory conditions such as rheumatoid arthritis, Crohn's disease and psoriasis. The levels of serum drug and ADA concentrations are monitored in patients receiving TNFα antagonists to help guide clinical decision-making, optimise treatment, improve outcomes and reduce healthcare costs.
The recombinant monoclonal anti-idiotypic antibodies are generated using the Human Combinatorial Antibody Library (HuCAL) and CysDisplay, a proprietary method of phage display with guided selection methods to obtain highly targeted reagents. The recombinant production method also ensures a consistent and secure supply.
The anti-certolizumab pegol antibodies are approved for in vitro research and for commercial applications of in vitro testing services that support preclinical and clinical drug and biosimilar development and patient monitoring.