Does the ‘entourage effect’ explain the increase in antimicrobial efficacy and lack of resistance seen with fifth-generation silane quaternary compounds? Here, Andrew Kemp provides an overview of the development and use of such agents.
The ‘entourage effect’ described by Russo1 is based on the holism theory, which is credited to Aristotle, who said: “the whole is greater than the sum of the parts”. From a purist point of view, it is unlikely that he actually said those exact words.
Decontamination and disinfection are enormous subjects individually and can be of mind-boggling complexity. The activity of disinfectants against microorganisms depends on a number of factors, some of which are intrinsic qualities of the organism, while others involve the chemical and external physical environment.
Background
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