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Clinical flow cytometry: advances in techniques and instrumentation

Clinical flow cytometry continues to feature in an eclectic range of applications in routine laboratory medicine and in the research environment. In addition to its use in haematology and immunology, flow cytometry has a cutting-edge role in investigating diverse biological processes, and the latest system developments offer innovation and increasing ease of use.

Modern flow cytometry instruments with multiple lasers and fluorescence detectors mean that this technology continues to have a wide and ever-expanding range of applications in molecular biology, pathology and immunology. This wide applicability is due to the more precise phenotypic identification of target populations permitted by multiparametric analyses.

            Flow cytometry applications are ever increasing and cover a huge range of biological processes. The technological advances demonstrated by new instrumentation, software analysis and experimental components (microstructured or in fluorochrome development) mean that the technological advances often far outstrip the published literature in the public domain.

            This article begins with a look at some advances in the field and concludes with an introduction to the latest innovation in flow cytometry, the CE/IVD-marked DxFLEX 13-colour clinical flow cytometry system from Beckman Coulter Life Sciences.

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