Molecular specialist Bradley Horn looks at the application of LAMP technology to combat the growing problem of antimicrobial resistance, particularly in Gram-negative bacteria that increasingly demonstrate multidrug resistance.
Loop-mediated isothermal amplification (LAMP) is proving to be an increasingly powerful tool for time-sensitive clinical diagnostics by offering additional benefits over traditional polymerase chain reaction (PCR) technologies.1 Mast Group has applied LAMP to the detection of carbapenemase-producing organisms (CPO) making rapid molecular testing available to laboratories worldwide.
The problem
The increasing prevalence of Gram-negative infections exhibiting multidrug resistance has become one of the most significant threats to public health globally. Carbapenem antibiotics such as meropenem, imipenem, ertapenem and doripenem have traditionally been considered as the last resort for treating such infections; however, this is no longer the case. Over recent years there have been several outbreaks of CPOs that have caused widespread dissemination of resistance, and become endemic in numerous countries.2,3
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