Research and the reporting of interesting cases provide publication opportunities both for the seasoned professional and also those in the early stages of their career. The work reported below reflects first on the ongoing research into the role of T follicular helper cell subset analysis in primary immunodeficiency, and second on a patient with undetectable HbA1c which proved to be due to blood loss from a tumour.
Skewed T follicular helper cell subsets in common variable immunodeficiency
Skewed T follicular helper cell subsets may provide a mechanism to explain the heterogeneity found in patients presenting with CVID. Here, Charlotte Lee and colleagues set the scene as they embark on further research.
Common variable immunodeficiency (CVID) is one of the most common, clinically significant primary immunodeficiencies. It is a heterogeneous collection of disorders characterised by impaired antibody secretion.1–4 As a consequence of the failure to produce protective levels of antibodies, sinopulmonary infections are very common, with approximately 95% of patients suffering with pneumonia, bronchitis or sinusitis,2 and so chronic lung disease and bronchiectasis are frequently encountered complications. Patients with CVID therefore require replacement antibody therapy in order to improve their quality of life, reduce the frequency of infections, and enhance their survival.5
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