Phenomenex has introduced Clarity Oligo-MS columns for rapid and efficient LC/MS characterisation and quality control of synthetic RNA and DNA. Based on the company’s core-shell particle technology, the new C18 columns deliver significantly shorter run times than traditional media, along with increased resolution and sensitivity. With the high resolving power of Clarity Oligo-MS, impurities in complex synthetic mixtures can be separated from the peak of interest in less than 10 minutes.
These new Oligo-MS columns, which are part of the Clarity BioSolutions portfolio, are packed with either 2.6 µm or 1.7 µm particles, enabling high efficiency on any high-performance liquid chromatography (HPLC) or ultra-HPLC (UHPLC) platform. Clarity Oligo-MS 2.6 µm columns operate at reduced backpressures compared to other oligonucleotide-specific columns, delivering UHPLC performance on any LC instrument, and methods are easily transferable. Clarity Oligo-MS 1.7 µm columns boost the performance of existing sub-2 µm methods on high-pressure systems.
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