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Grant allocated for kinome research in early inflammatory arthritis

Cellzome has been awarded a Medical Research Council Pilot Industry Collaboration Grant with Professor Christopher Buckley and Dr Karim Raza in the Department of Rheumatology and Medical Research Council Centre for Immune Regulation at the University of Birmingham Medical School to profile the expressed kinome in early inflammatory arthritis.

The project brings together three elements: a cohort of well-characterised patients with very early inflammatory arthritis; refined ultrasound-guided joint aspiration and biopsy; and a new technology called Kinobeads that allow quantitative profiling of the expression levels and activation states of kinases isolated directly from patient cells.

David Simmons, Cellzome’s chief scientific officer said: “This award will allow us to use our innovative approach to kinase drug discovery based on Kinobeads to directly study the signatures of the expressed kinome in the very early stages of arthritis. We are very pleased to have been awarded the grant with the research group in Birmingham, a leader in the study of early inflammatory disease.”

www.cellzome.com

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