Syngene has announced that scientists at East Tennessee State University (ETSU) have detected proteins associated with the cytotoxic effects of vitamin E on prostate cancer cells, using Dymension, the company's twodimensional (2D) gel image analysis software.
From the analysis, they have isolated several proteins that are significantly up-regulated or down-regulated, which, when identified, could provide critical information for the design of more effective drugs for the treatment and prevention of prostate cancer.
Mr Christian Mbangha Muenyi, a research assistant at ETSU, explained: “In many studies, it has been shown that vitamin E is cytotoxic to some prostate cancer cell lines, so we want to find out what is happening at the molecular level during this induced cell death. We have been using a proteomics approach for several years but found that it was difficult and timeconsuming to manipulate gel images to obtain meaningful data using our previous analysis software. Since switching to Dymension, analysis has been more straightforward and Syngene has provided excellent technical support.”
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