Scientists funded by the Wellcome Trust have identified a key mechanism that enables malaria-infected red blood cells to stick to the walls of blood vessels and avoid being destroyed by the body’s immune system. The research, published recently in the journal Cell, highlights an important potential new target for antimalarial drugs.
Eight new proteins that transport the Plasmodium falciparum parasite’s ‘glue’ to the surface of infected red blood cells have been found, and the researchersn from the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, have shown that removing just one of these proteins prevents the infected red blood cells from sticking to the walls of blood vessels.
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