RECENT FEATURE ARTICLES

Now embarking on the final article in his series on method comparisons. Stephen MacDonald concludes with advice on preparation of the documentation and final report.

The detection of SARS-CoV-2 mutations and new, potentially more infectious and transmissible variants of the virus currently is exercising the minds of the scientific and commercial communities. PerkinElmer examines the various testing methodologies.

Gemma Vanstone recounts how she discovered the molecular EntericBio system, and the positive impact that clinicians and patients can experience when a local pathology service works closely with Serosep and uses its range of real-time PCR tests.

Haemostasis capacity in the north-east of England has enjoyed significant benefits through collaboration with Stago UK. Here, staff from the South Tyne region explain how this collaboration has borne fruit in terms of compliance and efficiency.

Graham Johnson introduces the first non-invasive test for assessing the structure and function of the stomach in patients with dyspepsia. It can be used in the primary care setting and also in secondary care as a pre-endoscopy assessment tool.

It is almost a decade since it was shown that a strain of the endosymbiont Wolbachia that infects mosquitoes can make them resistant to the malaria parasite. Wolbachia can also have an impact on dengue, Zika and other mosquito-transmitted diseases.

At Torbay Hospital in Torquay, the microbiology and orthopaedic departments collaborated to implement point-of-care testing for methicillin-resistant Staphylococcus aureus to increase bed occupancy and enhance patient experience.

During the current SARS-CoV-2 pandemic, point-of-care testing (POCT) is proving invaluable in facilitating the easing of restrictions and a return to normality. The following examples illustrate how this technology is being applied and assessed.

The 35th Annual Scientific Conference of the BSMT took place online on 11–14 May. Not surprisingly, the focus was on one topic, COVID-19, with a particular focus on laboratory aspects of the pandemic. Mark Wilks reports on behalf of the committee.

Laboratories in Buckinghamshire, Milton Keynes, Oxfordshire and Swindon will use the CliniSys WinPath Enterprise system to deliver a consistent, high-quality and equitable service and build a platform for innovation across the pathology partnership.

The CN-3000 and CN-6000 models from Sysmex are joined by the CN-3500 and CN-6500 systems to provide laboratories with advanced immunological testing capabilities, and connectivity of these systems by the intelligent Laboratory Automation solution.

Mutations to the SARS-CoV-2 genome, particularly to those sequences responsible for the spike protein on the viral surface, are causing concern. Recent research has looked at the findings of studies undertaken over the past 12 months.

In March next year, the biennial IBMS Congress will return to the International Convention Centre in Birmingham. The event will focus once again on the very best that biomedical science and commercial colleagues have to offer.

Of the hundreds of millions of diabetes cases globally, 90% are estimated to be type 2 diabetes mellitus. Although T2DM is more common in adults, as obesity in children, teenagers and young adults has increased, so too has the incidence of T2DM.

Sheila Devaney looks at the training Roche offers pathologists using the PD-L1 tests for non-small cell lung cancer and triple-negative breast cancer, and the development of algorithms to support the diagnosis and targeted treatment of cancer.

With the recent announcement about reducing bureaucracy and the publication of a consultation document, the time is ripe to look at how managing data more efficiently can have a dramatic impact on improving patient safety, as Phil Taylor explains.

In this penultimate article in his series on method comparisons, Stephen MacDonald moves on from difference analysis and the contribution of Bland and Altman to consider qualitative methods and also the role of McNemar, Yates and Cohen.

Plasma viscosity is significantly increased in patients testing positive for SARS-CoV-2. This fast, inexpensive and accurate test can aid in the identification of positive cases and potential to monitor disease progression, as Dan Gleghorn explains.

An important partnership between Beckman Coulter and Worcestershire Acute Hospitals NHS Trust has resulted in the equipping of hospitals in the trust with up-to-date laboratory solutions at the cutting edge of analyser technology.

In addition to the effects of SARS-CoV-2 infection on the major organ systems of the body, there may also be reproductive consequences that go beyond the capacity to survive a viral attack from this pandemic agent of disease.